3DO controller on Genesis

Is it OK to use the 3DO controller on the Genesis?

I came home to discover my wife had pulled out the 3DO controller to use on my genesis. She insists it's a genesis controller, and claims that it worked fine.

I looked up on a 3DO FAQ and it says that the other way around, using a genesis controller on a 3DO, could damage both the controller and the 3DO. So obviously I'm concerned about using a 3DO controller on a genesis.

But I'm thinking that maybe the only reason it's bad to use a genesis controller on a 3DO is because the 3DO sends an audio signal on one of the pins (since the 3DO controller has a headphone jack). Since the Genesis doesn't do anything like that, it's probably safe.

Are there 3DO and Genesis controllers really button-for-button compatible other than that?
 
As far as I know, 3DO controllers are completely incompatible with Genesis controllers. 3DO controllers send their data serially while Genesis controllers mostly send their data in parallel.
 
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