It is possible to play us games on a pal system. Many games have a region lock, they will not run, but other have none. Some games run if you press the reset button. For example Spiderman the web of fire, Wrestlemania, Blackthorne or Tempo have no lock, otherwise Pitfall for example has a lock, but you can play it by pressing the reset button. But Virtua Fighter, Cosmic Carnage or star trek the starfleet Academy have a lock you can't get it run. The is one game Adapter wich can get even these title run, it is the Mega Key 2 all other will not work.
If you have any question, mail me (firstname.lastname@example.org). I can give you many information wich game works or not.