I just picked using Excel (or any free spreadsheet program). I looked at Access once, but it took so much effort just to create the record types and field options. With a spreadsheet, I could just create one header row with the fields, and then fill them in. And the drag+fill features make it easy to copy field values across multiple selections (and the auto-complete sometimes helps, and sometimes is annoying, but sometimes it's nice to be able to just type "Ge" and it fills in "Genesis" for you).
And any queries I'd want to make with a database I can accomplish with the auto-filter feature of the spreadsheet. For instance, pretty much the only queries I do are searching for all games by one system, or searching for all games missing the manual, or something like that. And auto-filter handles that perfectly.
And for the random info I put into the "condition" field, I can just use regular CTRL+F search to find it.
I usually never like software that pre-categorizes things for me. Like most on-line game databases always categorize all games generically as "shooter" or "simulation" or something. I'm quite picky about whether my game is a horizontal, vertical, 1st person, 3rd person, or isometric shooter, and know the difference between a platform shooter, an action platform, a beatemup, and an adventure game.
Like all those music organized softwares that are bundled with everything... I hate how they force-categorize all your music into their imaginary world of "genre". Everything is either "rock/alternative" or pop or country... and they're usually all categorized wrong anyway. I'm quite picky about which of my CDs are melodic metal, prog metal, neo-classical metal, symphonic metal, 80's metal, true metal, power metal, power-prog metal, and opera-metal. None of which would I be caught dead classifying as "rock/alt"...
Here's a small sample of my spreadsheet format (html output from excel, so it might not work in anything but IE 7):
http://www.jedimasterthrash.com/sega/GameDB.htm
The most handy use of the database was for finding missing parts. For instance, I could never remember if I needed an extra power supply or an extra Rf switch for all my genesii. Or which games I'm missing manuals to. And then of course should I be dumb enough to go to DiscLand's 20% sale or manage to get over to Hi-Score of Toyriffic, well then I definitely better remember which games I already have. The other purpose was just for figuring out which game I should play. For instance, if I have a friend over, I might want to find all the 2-player shooters and pick one. Or I can search for games without a filled-in Category field, because then I know I haven't even tried them out yet...