Really there isn't anything specific. I know that sounds lame, but it's just one of those deals where you're playing and you wonder if you're doing something wrong, or right for that matter and you want to flip through the manual. But when I play again and there's something I need/want to know I will post again.
The one thing I would like to know is boosting your cash flow month by month. I do develop Industry...but hey, I'm conquering the world, I need some flow!